I too do not like confrontation; However, I have ran across one of my close classmates in college of her husband having a profile on a dating website I was on…. I screenshotted his profile and the conversations.. that conversation did not last long. As heartbreaking as it is she ended up finding out from other friends about his infidelity.
Honestly, if it is your friend I would nonchalantly be like, hey man, is everything ok with you and your wife? (Just small talk, if he asks bring it up). I saw your wife at so and so, and she wasn’t with you… it could be a brother, cousin or someone else. But it also could be her identical twin sister and not her… My sisters are identical twins and they get this all the time.

Thank you for your comment, Jenni.